Lab for Affective and Translational Neuroscience

Lab for Affective and Translational Neuroscience

Working to understand the functional neuroanatomy of depression

Using a multi-modal approach spanning different levels of analyses (e.g., environment, genes, brain, behavior), LATN scientists are working towards a better understanding of the causes, consequences, and pathophysiology of depression.

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Novel psychological treatments for adolescent depression

Novel psychological treatments for adolescent depression

The Child and Adolescent Mood Disorders Laboratory is evaluating novel treatments based on cognitive, behavioral, and interpersonal approaches to mitigate stress and attenuate depressive symptoms among adolescents.

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The Center for Depression, Anxiety and Stress Research (CDASR) embraces a multi-disciplinary approach to improve our understanding of the psychological, environmental, and neurobiological factors associated with affective disorders.

The Center is home to many research projects, including studies that: utilize neuroimaging techniques to investigate the neurobiology of depression; implement and evaluate novel prevention and treatment programs for depressed adolescents; test the role of early adversities (e.g., maltreatment, trauma) and genetic variance in increasing the risk for depression and anxiety; explore psychological and neurobiological traits associated with resilience; and build computational models to study neural function in severe mental illnesses. Our goal is to identify promising targets for prevention and treatment.

Director's Message

Diego A Pizzagalli, Ph.D. is Director of the Center for Depression, Anxiety and Stress Research, and a Professor of Psychiatry at Harvard Medical School. Read More...

Upcoming Events

Wed Oct 5, 2016 at 9:30
DeMarneffe 218

Guia​ ​Guffanti Masetti, PhD
McLean Hospital

The role of long noncoding RNAs in PTSD

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Wed Oct 19, 2016 at 9:30
DeMarneffe 218

Matt Nassar, PhD
Brown University

Predicting influence with predictive inference

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Latest News

Christian Webb was recently awarded the 25th annual Alfred Pope Award for Young Investigators, McLean's highest research honor. Christian received the award for research focused on clarifying the etiology and underlying pathophysiology of depression. The award ceremony was covered in a recent edition of McLean News. Congratulations Christian!

Elizabeth Olson has received an Alies Muskin Career Development Leadership Program award from the Anxiety and Depression Association of America (ADAA). This is a highly competitive program that provides mentoring and professional development opportunity for early career clinicians and researchers.

Jeremy Stewart is the 2016 recipient of the HMS Kaplen Fellowship on Depression Award. In addition, Jeremy was recently awarded a Livingston Fellowship for his project entitled “Examining Behavioral and Neural Mechanisms Underlying Suicidality in Depressed Adolescents.”