Lab for Affective and Translational Neuroscience

Lab for Affective and Translational Neuroscience

Working to understand the functional neuroanatomy of depression

Using a multi-modal approach spanning different levels of analyses (e.g., environment, genes, brain, behavior), LATN scientists are working towards a better understanding of the causes, consequences, and pathophysiology of depression.

Novel psychological treatments for adolescent depression

Novel psychological treatments for adolescent depression

The Child and Adolescent Mood Disorders Laboratory is evaluating novel treatments based on cognitive, behavioral, and interpersonal approaches to mitigate stress and attenuate depressive symptoms among adolescents.

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The Center for Depression, Anxiety and Stress Research (CDASR) embraces a multi-disciplinary approach to improve our understanding of the psychological, environmental, and neurobiological factors associated with affective disorders.

The Center is home to many research projects, including studies that: utilize neuroimaging techniques to investigate the neurobiology of depression; implement and evaluate novel prevention and treatment programs for depressed adolescents; test the role of early adversities (e.g., maltreatment, trauma) and genetic variance in increasing the risk for depression and anxiety; explore psychological and neurobiological traits associated with resilience; and build computational models to study neural function in severe mental illnesses. Our goal is to identify promising targets for prevention and treatment.

Director's Message

Diego A Pizzagalli, Ph.D. is Director of the Center for Depression, Anxiety and Stress Research, and a Professor of Psychiatry at Harvard Medical School. Read More...

Upcoming Events

Wed Nov 18, 2015 at 9:30
DeMarneffe 218

Marie-France Marin, Ph.D.
Massachusetts General Hospital
Harvard Medical School

Functional neuroimaging of fear conditioning and extinction in anxiety disorders


Wed Dec 9, 2015 at 9:30
DeMarneffe 218

Alexis Whitton, Ph.D.
McLean Hospital
Instructor of Psychiatry, Harvard Medical School

Abnormalities in reward and error processing that persist beyond depression remission


Latest News

Alexis Whitton PhD

Alexis Whitton was recently promoted to Instructor in Psychiatry at Harvard Medical School. Congratulations to Dr. Whitton!



A number of CDASR lab members have recently received significant grants and awards.  Poornima Kumar has been awarded an NIMH grant for her study entitled “Influence of GABA on reinforcement learning in individuals with current and remitted depression.”  Christian Webb has been awarded a Klingenstein Third Generation Fellowship Award in Depression, for a longitudinal fMRI study of children with anhedonia. Finally, Stephanie Deccy and Melissa Yuan, two of our undergraduate researchers, have each been awarded a Harvard College Research Program (HCRP) grant to support their work in the center during the summer.  Congratulations to all on your achievements!

Janice Kiley, Grants Administrator for the Center for Depression, Anxiety and Stress Research, was recently honored as a recipient of McLean Hospital’s Vision of Excellence (VoE) Award, for her commitment to excellence and  her consistent efforts to go above and beyond. At the award reception Janice was applauded by McLean President, Scott L. Rauch, MD, Chief Academic Officer Shelly M. Greenfield, MD, and CDASR Director  Diego A. Pizzagalli, PhD, along with dozens of colleagues and friends who came to express their appreciation for Janice's exceptional support. Congratulations, Janice!