Lab for Affective and Translational Neuroscience

Lab for Affective and Translational Neuroscience

Working to understand the functional neuroanatomy of depression

Using a multi-modal approach spanning different levels of analyses (e.g., environment, genes, brain, behavior), LATN scientists are working towards a better understanding of the causes, consequences, and pathophysiology of depression.

Novel psychological treatments for adolescent depression

Novel psychological treatments for adolescent depression

The Child and Adolescent Mood Disorders Laboratory is evaluating novel treatments based on cognitive, behavioral, and interpersonal approaches to mitigate stress and attenuate depressive symptoms among adolescents.

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The Center for Depression, Anxiety and Stress Research (CDASR) embraces a multi-disciplinary approach to improve our understanding of the psychological, environmental, and neurobiological factors associated with affective disorders.

The Center is home to many research projects, including studies that: utilize neuroimaging techniques to investigate the neurobiology of depression; implement and evaluate novel prevention and treatment programs for depressed adolescents; test the role of early adversities (e.g., maltreatment, trauma) and genetic variance in increasing the risk for depression and anxiety; explore psychological and neurobiological traits associated with resilience; and build computational models to study neural function in severe mental illnesses. Our goal is to identify promising targets for prevention and treatment.

Director's Message

Diego A Pizzagalli, Ph.D. is Director of the Center for Depression, Anxiety and Stress Research, and a Professor of Psychiatry at Harvard Medical School. Read More...

Upcoming Events

Wed May 31, 2017 at 9:30
DeMarneffe 218

Theresa Desrochers, PhD
Brown University

"Sequence monitoring in the frontal cortexr"


Latest News

Christian Webb was recently promoted to Assistant Professor in Psychiatry at Harvard Medical School. Congratulations to Dr. Webb!


Elizabeth Olson, Roselinde Kaiser, and Jeremy Stewart have each received a NARSAD Investigator award. Liz will explore neural circuits that link PTSD with other mental disorders including suicidal behavior. Dr. Kaiser will investigate how large-scale brain networks involved in cognitive control might be affected in mood disorders.  Jeremy will seek to identify predictors of suicide attempts in high-risk adolescents using EEG to measure their sensitivity to rejection.




Christian Webb was recently awarded the 25th annual Alfred Pope Award for Young Investigators, McLean's highest research honor. Christian received the award for research focused on clarifying the etiology and underlying pathophysiology of depression. The award ceremony was covered in a recent edition of McLean News. Congratulations Christian!