Yuen Siang Ang, DPhil

Postdoctoral Research Fellow

Laboratory for Affective and Translational Neuroscience

McLean Hospital/Harvard Medical School

Office: deMarneffe Building, office 233B
Phone: 617-855-4429

Email: yang@mclean.harvard.edu

D.Phil., Clinical Neurosciences, University of Oxford, 2018

B.Sc., Applied Physics, Nanyang Technological University, Singapore, 2013

Yuen Siang Ang

Research Interests

Deficits in motivation (e.g. apathy, anhedonia) are profoundly disabling and prevalent in neurodegenerative diseases, such as Parkinson’s and Alzheimer’s disease, and psychiatric disorders, such as Major Depressive Disorder and schizophrenia. My research uses computational modelling, functional neuroimaging and pharmacological challenge techniques to understand how impairments during decision making in humans may contribute to reduced goal-directed behaviour in these conditions. My work chiefly focuses on elucidating the neurobiological basis of option generation and examining how the ability to self-generate options for behaviour is related to motivation in health and disease. During my DPhil in Oxford, I devised a quantitative and objective measure of option generation and provided the first causal evidence for dopamine playing an important role in modulating this process during decision making. (see Ang et al. 2018, Current Biology). I am also interested in understanding how deficiencies in cost-benefit analyses during the evaluation of options may lead to decreased motivation to act. Finally, I am investigating the multidimensional constructs of apathy (see Ang et al. 2017, PLoS One). The overall goal of my research is to improve diagnostic precision and enhance treatment efficacy of motivational dysfunction across diagnoses.

Personal website: www.yuensiangang.co.nf