Selected Examples of Ongoing Studies

Using a multi-disciplinary approach, CDASR scientists aim to fundamentally improve our understanding of the psychological, environmental, and neurobiological factors associated with depression, anxiety and related disorders.

Currently, CDASR scientists are devoting their efforts to answer the following research questions:

Q) Can neuroimaging guide treatment selection for depression, leading to improvements in efficacy, speed of symptom reduction, and cost-effectiveness relative to current approaches?

Q) Can we identify neural markers associated with vulnerability to depression and PTSD before disease onset or trauma exposure?

Q) What is the psychological and neurobiological signature of resilience, and what characterizes individuals who face severe adversity but do not develop mental illness?

Q) Can we identify genetic variants that reliably increase the risk for depression and anxiety disorders, particularly via interactions with environmental stressors?

Q) What are the psychological and neurobiological consequences of childhood adversities such as neglect and maltreatment, which have been linked to a 5-fold increase in rates of adult depression?

Q) How can we design more effective psychological treatments for childhood and adolescent depression, taking into account the range of cognitive, interpersonal, and environmental variables that may render certain children vulnerable to depression? 

Q) Can we develop cognitive training that target neural abnormalities of depression and anxiety disorders to accelerate recovery and/or increase resiliency?

Q) How effective is internet-based cognitive behavioral therapy (i-CBT) for depression?

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