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Publications in Press

Berghorst, L.H.*, Kumar, P.*, Greve, D.N., Deckersbach, T., Ongur, D., Dutra, S., Pizzagalli, D.A. (in press). Stress and reward processing in bipolar disorder: An fMRI study. Bipolar Disorders. [*Co-first authors]

Jensen, J.E.*, Auerbach, R.P.*, Pisoni, A., Pizzagalli, D.A. (in press). Localized MRS reliability of in vivo glutamate at 3 Tesla in shortened scan times: A feasibility study. NMR in Biomedicine. [*Co-first authors]

Moran, L.V., Stoeckel, L.E., Wang, K., Caine, C.E., Villafuerte, R., Calderon, V., Baker, J.T., Ongur, D., Janes, A.C., Pizzagalli, D.A.*, Evins, A.E.* (in press). Nicotine increases activation to anticipatory valence cues in anterior insula and striatum. Nicotine & Tobacco Research [*Equal senior contributions.]

Pizzagalli, D.A., Whitton, A.E., Webb, C.A. (in press). Mood Disorders. In James N. Butcher, Jill Hooley, Philip D. Kendall (Eds). APA Handbook of Psychopathology, American Psychological Association.

Treadway, M.T.*, Admon, R.*, Arulpragasam, A.R., Mehta, M., Douglas, S., Vitaliano, G., Olson, D.P., Cooper, J.A., Pizzagalli, D.A. (in press). Association between interleukin-6 and striatal prediction-error signals following acute stress in healthy females. Biological Psychiatry. [*Contributed equally]

Whitton, A.E., Deccy, S., Ironside, M.L., Kumar, P., Beltzer, M., Pizzagalli, D.A. (in press). EEG source functional connectivity reveals abnormal high-frequency communication among large-scale functional networks in depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

2011 Publications

Bogdan, R., Santesso, D.L., Fagerness, J., Perlis, R.H., Pizzagalli, D.A. (2011). Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning. Journal of Neuroscience, 31, 13246-13254. PDF

Denninger, J.W., van Nieuwenhuizen, A.O, Wisniewski, S.R., Luther, J.F., Trivedi, M.H., Rush, A.J., Gollan, J.K., Pizzagalli, D.A., Fava, M. (2011). Changes in depressive symptoms and social functioning in STAR*D. Journal of Nervous and Mental Disease, 199, 807-810. PDF

Dillon, D.G., Deveney, C.M., Pizzagalli, D.A. (2011). From basic processes to real-world problems: How research on emotion and emotion regulation can inform understanding of psychopathology, and vice versa. Emotion Review, 3, 74–82. PDF

Koslov, K., Mendes, W.B., Pajtas, P.E., Pizzagalli, D.A. (2011). Asymmetry in resting intracortical activity as a buffer to social threat. Psychological Science, 22, 641-649. PDF

Pechtel, P., Pizzagalli, D.A. (2011). Effects of early life stress on cognitive and affective function: An integrated review of human literature. Psychopharmacology, 214, 55-70. PDF

Pizzagalli, D.A. (2011). Frontocingulate dysfunction in depression: Towards biomarkers of treatment response. Neuropsychopharmacology Review, 36, 183-206. PDF

2012 Publications

AhnAllen, C.G., Liverant, G.I., Gregor, K.L., Kamholz, B.W., Levitt, J., Gulliver, S.B., Pizzagalli, D.A., Koneru, V., Kaplan, G. (2012). The relationship between reward-based learning and nicotine dependence in smokers with schizophrenia. Psychiatry Research, 196, 9-14. PDF

Bogdan, R., Pringle, P., Goetz, E.L., Pizzagalli, D.A. (2012). Perceived stress, anhedonia and illusion of control: Evidence for two meditational models. Cognitive Therapy and Research, 36, 827-832. PDF

Dutra, S.J., Stoeckel, L.E., Carlini, S.V., Pizzagalli, D.A.*, Evins, A.E.* (2012). Varenicline as a smoking cessation aid in schizophrenia: Effects on smoking behavior and reward sensitivity. Psychopharmacology, 219, 25-34 [*Contributed equally as senior authors]. PDF

Grob, S., Pizzagalli, D.A., Dutra, S.J., Stern, J., Mörgeli, H., Milos, G., Schnyder, U., Hasler, G. (2012). Dopamine-related deficit in reward learning after catecholamine depletion in unmedicated, remitted subjects with Bulimia Nervosa. Neuropsychopharmacology, 37, 1945-1952. PDF

Millner, A.J., Jaroszewski, A.C., Chamarthi, H., Pizzagalli, D.A. (2012). Behavioral and electrophysiological correlates of training-induced cognitive control improvements. NeuroImage, 63, 742-753. PDF

Nikolova, Y., Bogdan, R., Pizzagalli, D.A. (2012). Perception of a naturalistic stressor interacts with 5-HTTLPR genotype and gender to impact reward responsiveness. Neuropsychobiology, 65, 45-54. PDF

Santesso, D.L., Bogdan, R., Birk, J.L., Goetz, E.L., Holmes, A.J., Pizzagalli, D.A. (2012). Neural responses to negative feedback are related to negative emotionality in healthy adults. Social Cognitive and Affective Neuroscience, 7, 794-803. PDF

Vanderhasselt, M.A., De Raedt, R., Dillon, D.G., Dutra, S.J., Brooks, N., Pizzagalli, D.A. (2012). Decreased cognitive control in response to negative information in remitted depression: An Event Related Potential study. Journal of Psychiatry and Neuroscience, 37, 250-258. PDF

2013 Publications

Berghorst, L.H., Bogdan, R., Frank, M.J., Pizzagalli, D.A. (2013). Acute stress selectively reduces reward sensitivity Frontiers in Human Neuroscience 7:133. doi:10.3389/fnhum.2013.00133. PDF

Bogdan R., Nikolova, Y.S., Pizzagalli, D.A. (2013). Neurogenetics of depression: A focus on reward processing and stress sensitivity. Neurobiology of Disease, 52, 12-23. PDF

Der-Avakian, A., D’Souza, M.S., Pizzagalli, D.A.*, Markou, A.* (2013). Assessment of reward responsiveness in the Response Bias Probabilistic Reward Task in rats: Implications for cross-species translational research. Translational Psychiatry 3, e297; doi:10.1038/tp.2013.74 [*Contributed equally as senior authors]. PDF

Dillon, D.G., Pizzagalli, D.A. (2013). Evidence of successful modulation of brain activation and subjective experience during reappraisal of negative emotion in unmedicated depression. Psychiatry Research: Neuroimaging, 212, 99-107. PDF

Goetz, E.L., Hariri, A.R., Pizzagalli, D.A., Strauman, T.J. (2013). Genetic moderation of the association between regulatory focus and reward responsiveness: A proof-of-concept study. Biology of Mood & Anxiety Disorders. 2013 Feb 1;3(1):3. doi: 10.1186/2045-5380-3-3. PDF

Huys, Q.J.M, Pizzagalli, D.A., Bogdan, R., Dayan, P. (2013). Mapping anhedonia onto reinforcement learning: A behavioural meta-analysis. Biology of Mood & Anxiety Disorders. 2013, 3:12. PDF

Janes, A.C., Jensen, J.E., Farmer, S.L., Frederick, B.D., Pizzagalli, D.A., Lukas, S.E. (2013). GABA levels in the dorsal anterior cingulate cortex associated with difficulty ignoring smoking-related cues in tobacco-dependent volunteers. Neuropsychopharmacology, 38, 1113-1120. PDF

Pechtel, P., Dutra, S.J., Goetz, E.L., Pizzagalli, D.A. (2013). Blunted reward responsiveness in remitted depression. Journal of Psychiatric Research, 47, 1864-1869. PDF

Pechtel, P., Pizzagalli, D.A. (2013). Disrupted reinforcement learning and maladaptive behavior in women with a history of childhood sexual abuse: A high-density event-related potential study. JAMA Psychiatry, 70, 499-507. PDF

Vrieze, E., Ceccarini, J., Pizzagalli, D.A., Bormans, G., Vandenbulcke, M., Demyttenaere, K., Van Laere, K., Claes S. (2013). Measuring extrastriatal dopamine release during a reward learning task. Human Brain Mapping, 34, 575-586. PDF

Vrieze, E., Pizzagalli, D.A., Demyttenaere, K., Hompes, T., Sienaert, P., de Boer, P., Schmidt, M., Claes S. (2013). Reduced reward learning predicts outcome in Major Depressive Disorder. Biological Psychiatry, 73, 639-645. PDF

Wacker, J., Mueller, E.M., Pizzagalli, D.A., Hennig, J., Stemmler, G. (2013). Dopamine-D2-receptor blockade reverses the association between trait approach motivation and frontal asymmetry in an approach-motivation context. Psychological Science, 24, 489-497. PDF

2014 Publications

Abramovitch, A., Reuman, L., Pizzagalli, D.A., Wilhelm, S. (2014). Anhedonia in Obsessive-Compulsive Disorder: Beyond comorbid depression. Psychiatry Research, 216, 223-229.  PDF

Auerbach, R.P., Admon, R., Pizzagalli, D.A. (2014). Adolescent depression: Stress and reward dysfunction. Harvard Review of Psychiatry, 22, 139-148. PDF

Chumbley, J.R, Hulme, O., Köchli, H., Russell E., Van Uum, S., Pizzagalli D.A., Fehr, E. (2014). Stress and reward: Long term cortisol exposure predicts the strength of sexual preference. Physiology & Behavior, 131, 33-40.  PDF

Dillon, D.G., Dobbins, I.G., Pizzagalli, D.A. (2014). Weak reward source memory in depression reflects blunted activation of VTA/SN and parahippocampus. Social Cognitive and Affective Neuroscience, 9, 1576-1583. PDF

Dillon, D. G., Rosso, I. M., Pechtel, P., Killgore, W. D. S., Rauch, S. L., Pizzagalli, D.A. (2014). Peril and pleasure: an RDoC-inspired examination of threat responses and reward processing in anxiety and depression. Depression and Anxiety, 31, 233-249.  PDF

Kumar, P., Berghorst, L.H., Nickerson, L.D., Dutra, S.J., Goer, F., Greve, D., Pizzagalli, D.A. (2014). Differential effects of acute stress on anticipatory and consummatory phases of reward processing. Neuroscience, 266, 1-12. PDF

Liverant, G.I., Sloan, D.M., Pizzagalli, D.A., Harte, C.B., Kamholz, B.W., Rosebrock, L.E., Cohen, A.L., Fava, M., Kaplan, G.B. (2014). Associations among smoking, anhedonia, and reward learning in depression. Behavior Therapy, 45, 651-663. PDF

Mueller, E.M., Panitz, C., Hermann, C., Pizzagalli, D.A. (2014). Prefrontal oscillations during recall of conditioned and extinguished fear in humans. Journal of Neuroscience, 34, 7059-66.  PDF

Pergadia, M.L., Der-Avakian, A., D'Souza, M.S., Madden, P.A.F., Heath, A.C., Shiffman, S., Markou, A., Pizzagalli, D.A. (2014). Withdrawal of nicotine blunts reward responsiveness in humans and rats. JAMA Psychiatry, 71, 1238-1245. PDF

Pizzagalli, D.A. (2014). Depression, stress, and anhedonia: Toward a synthesis and integrated model. Annual Review of Clinical Psychology, 10, 393-423. PDF

Treadway, M.T., Pizzagalli, D.A. (2014). Imaging the pathophysiology of Major Depressive Disorder – From localist models to circuit-based analysis. Biology of Mood & Anxiety Disorders. 2014 4:5.  PDF

Vrieze, E., Demyttenaere, K., Bruffaerts, R., Hermans, D., Pizzagalli, D.A., Sienaert, P., Hompes, T., de Boer, P., Schmidt, M., Claes S. (2014). Dimensions in major depressive disorder and their relevance for treatment outcome. Journal of Affective Disorders, 155, 35-41. PDF


2015 Publications

Abramovitch, A., Pizzagalli, D.A., Geller, D.A., Reuman, L., Wilhelm, S. (2015). Cigarette smoking in obsessive-compulsive disorder and unaffected parents of OCD patients. European Psychiatry, 30, 137-144. (PDF)

Admon, R., Holsen, L.M., Aizley, H., Remington, A., Whitfield-Gabrieli, S., Goldstein, J.M., Pizzagalli, D.A. (2015). Striatal hyper-sensitivity during stress in remitted individuals with recurrent depression. Biological Psychiatry, 78, 67-76. (PDF)

Admon, R., Nickerson, L.D., Dillon, D.G., Holmes, A.J., Bogdan, R., Kumar, P., Dougherty, D.D., Iosifescu, D.V., Mischoulon, D., Fava, M., Pizzagalli, D.A. (2015). Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties. Psychological Medicine, 45, 121-31. (PDF)

Admon, R., Pizzagalli, D.A. (2015). Corticostriatal pathways contribute to the natural time course of positive mood. Nature Communications. 6:10065 doi: 10.1038/ncomms10065. (PDF)

Admon, R., Pizzagalli, D.A. (2015). Dysfunctional reward processing in depression. Current Opinion in Psychology, 4, 114-118. (PDF)

Auerbach, R.P., Stanton, C.H., Proudfit, G.H., Pizzagalli, D.A. (2015). Self-referential processing in adolescent depression: A high-density ERP study. Journal of Abnormal Psychology, 124, 233-245. (PDF)

Beard, C., Donahue, R.J., Dillon, D.G., Van’t Veer, A., Webber, C., Lee, J., Barrick, E., Hsu, K.J., Foti, D., Carroll, F.Y, Carlezon, W.A.,  Jr., Björgvinsson, T., Pizzagalli, D.A. (2015). Abnormal error processing in depressive states: A Translational examination in humans and rats. Translational Psychiatry. (2015) 5, e564; doi:10.1038/tp.2015.54  (PDF)

Dillon, D.G.*, Wiecki, T.*, Pechtel, P., Webb, C., Goer, F., Murray, L., Trivedi, M., Fava, M., McGrath, P.J., Weissman, M., Parsey, R., Kurian, B., Adams, P., Carmody, T., Weyandt, S., Shores-Wilson, K., Toups, M., McInnis, M., Oquendo, M.A., Cusin, C., Deldin, P., Bruder, G., Pizzagalli, D.A. (2015). A computational analysis of Flanker interference in depression. Psychological Medicine, 45, 2333-2344. [*These authors made equal contributions.] (PDF)

Fletcher, K., Parker, G., Paterson, A., Fava M., Iosifescu, D., Pizzagalli, D.A. (2015). Anhedonia in melancholic and non-melancholic depressive disorders. Journal of Affective Disorders, 184, 81-88. (PDF)

Hsu, K.J., Beard, C., Rifkin, L., Dillon, D.G., Pizzagalli, D.A., Björgvinsson, T. (2015).  Transdiagnostic mechanisms in depression and anxiety: The role of rumination and attentional control. Journal of Affective Disorders, 188, 22-27. (PDF)

Janes, A.C.*, Pedrelli, P.*, Whitton, A.E., Pechtel, P., Douglas, S., Martinson, M.A., Huz, I., Fava, M., Pizzagalli, D.A.**, Evins, A.E.** (2015). Reward responsiveness varies by smoking status in women with a history of major depressive disorder. Neuropsychopharmacology, 40, 1940-1946 [*These authors made equal contributions; **These authors made equal senior contributions.]  (PDF)

Kaiser R.H., Andrews-Hanna J.R., Wager T.D., Pizzagalli D.A. (2015). Large-Scale Network Dysfunction in Major Depressive Disorder: A Meta-analysis of Resting-State Functional Connectivity. JAMA Psychiatry, 72(6):603-11. (PDF)

Kaiser, R.H, Pizzagalli, D.A. (2015). Dysfunctional connectivity in the depressed adolescent brain. Biological Psychiatry, 78, 594-595. (PDF)

Kumar, P., Slavich, G.M., Berghorst, L.H., Treadway, M.T., Brooks, N.H., Dutra, S.J., Greve, D.N., O'Donovan, A., Bleil, M.E., Maninger, N., Pizzagalli, D.A. (2015). Perceived chronic stress exposure modulates reward-related medial prefrontal cortex responses to acute stress in depression. Journal of Affective Disorders, 180, 104-111. (PDF)

Mueller, E.M., Panitz, C., Pizzagalli, D.A., Hermann, C., Wacker, J. (2015). Midline theta dissociates agentic extraversion and anhedonic depression. Personality and Individual Differences, 79, 172-177. (PDF)

Mueller, E.M., Pechtel, P., Cohen, A.L., Douglas, S.R., Pizzagalli, D.A. (2015). Potentiated processing of negative feedback in depression is attenuated by anhedonia. Depression and Anxiety, 32, 296-305. (PDF)

Peechatka, A.L., Whitton, A.E., Farmer, S.L., Pizzagalli, D.A., Janes, A.C. (2015). Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers. Drug and Alcohol Dependence, 155, 202-207. (PDF)

Treadway, M.T., Waskom, M.L., Dillon, D.G., Holmes, A.J., Park, M.T.M., Chakravarty, M.M., Dutra, S.J., Polli, F.E., Iosifescu, D.V., Fava, M., Gabrieli, J.D.E., Pizzagalli, D.A. (2015). Illness progression, recent stress and morphometry of hippocampal subfields and medial prefrontal cortex in Major Depression. Biological Psychiatry, 77, 285-294. (PDF)

Whitton, A.E., Treadway, M.T, Pizzagalli, D.A. (2015). Reward processing dysfunction in major depression, bipolar disorder and schizophrenia. Current Opinion in Psychiatry, 28, 7-12. (PDF)

2016 Publications

Auerbach, R. P., Bondy, E., Stanton, C. H., Webb, C. A., Shankman, S. A., & Pizzagalli, D. A. (2016). Self-referential processing in adolescents: Stability of behavioral and event-related potential markers. Psychophysiology, 53, 1398-1406. (PDF)

Auerbach, R.P., Tarlow, N., Bondy, E., Stewart, J.G., Aguirre, B., Kaplan, C., Yang, W., Pizzagalli, D.A. (2016). Electrocortical reactivity during self-referential processing in female youth with Borderline Personality Disorder. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1, 335-344. (PDF)

Corral-Frías, N.S., Pizzagalli, D.A., Carré, J, Michalski, L.J., Nikolova, Y.S., Perlis, R.H., Fagerness, J., Conley, E.D., Lee, M.R., Lancaster, T.M., Haddad, S., Wolf, A., Hariri, A.R., Smoller, J.W., Bogdan, R. (2016). A common genetic variant in Cathechol-O-methyl-transferase is associated with individual differences in reward-related response bias. Genes, Brain and Behavior, 15, 503-513. (PDF)

Der-Avakian, A., Barnes, S.A., Markou, A., Pizzagalli, D.A. (2016). Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders. Current Topics in Behavioral Neurosciences, 28, 231-262. (PDF)

Kaiser, R.H., Whitfield-Gabrieli, S., Dillon, D.G., Goer, F., Beltzer, M., Minkel, J., Smoski, M., Dichter, G., Pizzagalli, D.A. (2016). Dynamic resting-state functional connectivity in Major Depression. Neuropsychopharmacology, 41, 1822-1830. (PDF)

Lewandowski, K.E., Whitton, A.E., Pizzagalli, D.A., Norris, L.A., Ongur, D., Hall, M.H. (2016). Reward learning, neurocognition, social cognition, and symptomatology in psychosis. Frontiers in Psychiatry. 7:100.doi: 10.3389/fpsyt.2016.00100. (PDF)

Mueller, E.M., Pizzagalli, D.A. (2016). One year old fear memories rapidly activate human fusiform gyrus. Social Cognitive & Affective Neuroscience, 11, 308-316. (PDF)

Muench, H.M., Westermann, S., Pizzagalli, D.A., Hofmann, S.G., Mueller, E.M. (2016). Self-relevant threat contexts enhance early processing of fear-conditioned faces. Biological Psychology, 121, 194-202. (PDF)

Norton, D.J., McBain, R.K., Pizzagalli, D.A., Cronin-Golomb, A., Chen, Y. (2016). Dysregulation of visual motion inhibition in major depression. Psychiatry Research, 240, 214-221. (PDF)

Pizzagalli, D.A. (2016). Psychobiology of the intersection and divergence of depression and anxiety. Depression and Anxiety, 33, 891-894. (PDF)

Rizvi, S.J., Pizzagalli, D.A., Sproule, B.A., Kennedy, S.H. (2016). Assessing anhedonia in depression: Potentials and pitfalls. Neuroscience & Biobehavioral Reviews, 65, 21-35. (PDF)

Sawyer, A.T., Liverant, G.I., Jun, J.J., Lee, D.J., Cohen, A.L., Dutra, S.J., Pizzagalli, D.A., Sloan, D.M. (2016). Punishment learning in veterans with posttraumatic stress disorder. Journal of Traumatic Stress, 29, 374-378. (PDF)

Trivedi, M.H., McGrath, P.J., Fava, M., Parsey, R.V., Kurian, B.T., Phillips, M.L., Oquendo, M.A., Bruder, G., Pizzagalli, D., Toups, M., Cooper, C., Adams, P., Weyandt, S., Morris, D.W., Grannemann, B., Ogden, R.T., Buckner, R., McInnis, M., Kraemer, H.C., Petkova, E., Carmody, T.J., Weissman, M.M. (2016). Establishing moderators and biosignatures of antidepressant response in clinical care (EMBARC): Rationale and design. Journal of Psychiatric Research, 78, 11-23. (PDF)

Webb, C.A., Dillon, D.G., Pechtel, P., Goer, F., Murray, L., Huys, Q.J.M., Fava, M., McGrath, P.J., Weissman, M., Parsey, R., Kurian, B., Adams, P., Weyandt, S., Trombello, J., Grannemann, B., Cooper, C., Deldin, P., Tenke, C., Trivedi, M., Bruder, G., Pizzagalli, D.A. (2016). Neural correlates of three promising endophenotypes of depression: Evidence from the EMBARC study. Neuropsychopharmacology, 41, 454-463. (PDF)

Whitton, A.E., Kakani, P., Foti, D., Van’t Veer, A., Haile, A., Crowley, D.J., Pizzagalli, D.A. (2016). Blunted neural responses to reward in remitted Major Depression: A high-density event-related potential study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1, 87-95. (PDF)

2010 Publications

Bogdan, R., Perlis, R.H., Fagerness, J., Pizzagalli, D.A. (2010). The impact of Mineralocorticoid Receptor ISO/VAL genotype (rs5522) and stress on reward learning. Genes, Brain and Behavior, 9, 658-667. PDF

Dillon, D.G., Bogdan, R., Fagerness, J., Holmes, A.J., Perlis, R.H., Pizzagalli, D.A. (2010). Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans. Human Brain Mapping, 31, 210-221. PDF

Holmes, A.J., Bogdan, R., Pizzagalli, D.A. (2010). Serotonin transporter genotype and action monitoring dysfunction: A possible substrate underlying increased vulnerability to depression. Neuropsychopharmacology, 35, 1186-1197. PDF

Holmes, A.J., Pizzagalli, D.A. (2010). Effects of task-relevant incentives on the electrophysiological correlates of error processing in Major Depressive Disorder. Cognitive, Affective, and Behavioral Neuroscience, 10, 119-128. PDF

Janes, A.C., Pizzagalli, D.A., Richardt, S., Frederick, B.D., Chuzi, S., Pachas, G., Culhane, M.A., Holmes, A.J., Fava, M., Evins, A.E., Kaufman, M.J. (2010). Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence. Biological Psychiatry, 67, 722-729. PDF

Janes, A.C., Pizzagalli, D.A., Richardt, S., Frederick, B.B., Holmes, A.J., Sousa, J., Fava, M., Evins, A.E., Kaufman, M.J. (2010). Neural substrates of attentional bias for smoking-related cues: an fMRI study. Neuropsychopharmacology, 35, 2339-2345. PDF

Lempert, K.M., Pizzagalli, D.A. (2010). Delay discounting and future-directed thinking in anhedonic individuals. Journal of Behavior Therapy and Experimental Psychiatry,41, 258-264. PDF

Pizzagalli, D.A. (2010). The "anhedonia paradox" in schizophrenia: Insights from affective neuroscience. Biological Psychiatry, 67, 899-901. PDF

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